Charged macromolecules, dispersed in aqueous media, are ubiquitous and are manifest in all forms and functions of all Life. Inevitably, charged macromolecules exhibit a variety of enigmatic puzzles that are unprecedented in uncharged polymers. Examples include (1) even similarly charged polymers clump together under conditions of extreme electrostatic repulsion, (2) diffusion of gigantic charged macromolecules can be as high as that of a small metallic ion exhibiting the “ordinary-extraordinary” transition, (3) apparent violation of Einstein’s law of diffusion in crowded aqueous media at room temperature even if we were to wait for very long times comparable to the age of the universe, and (4) polymers made of neutral-polar monomers can move under an electric field, but only in one direction and never in the opposite direction. We identify the nucleus of these enigmatic phenomena as the confluence of concurrent occurrence of three long-ranged correlations arising from the chain connectivity, electrostatics, and hydrodynamics. We will highlight the fundamental principles behind charged macromolecules in unraveling the above puzzles. Implications of these principles are abundant in Life processes and technological innovations.