Tannins are natural polyphenols with relevant biological properties ranging from antioxidant to antimicrobial activity.Tannins self-assembly behaviour has not yet been studied in detail.[1] However, the presence of hydroxyl and phenolic groups along with aromatic rings, expectedly results in both long-range interactions (e.g. van der Waals, electrostatic forces and hydrophobic interaction) and short-range interactions (e.g. H-bonds and π-π interactions).[2]In this context, an array of different hydrolysable and condensed tannins was used in the frame of a comprehensive study of their aggregation mechanisms. More specifically, focusing on colloidal aggregation processes,  different solvents, sample concentrations, and other variables including pH, ionic strength, and temperature were modified based on the same approach that were essential to controlling lignin aggregates.[3]The study of this material provides the first step in the investigation of the aggregation of tannins, with the aim to prepare pure tannins nanoparticles.The structural peculiarity of the aggregates displayed in the DLS (Dynamic Light Scattering) was correlated to the structure of tannins as evaluated by 31P NMR, 1H/13C HSQC, MALDI, GC-MS, and HPLC.[4,5 6]