Poster

P5.7 – Fabrication of cellulose-based hydrogel-coated micrometer-scale neural electrodes for noninvasive peripheral nerve stimulation

Hao Zhang

Laboratory of Organic Electronics, Linköping University

Co-author(s):
Mary Donahue, Laboratory of Organic Electronics, Linköping University

Over the past decades, neural electrodes have been widely used in research and therapeutic applications for neuropsychiatric disorders such as Alzheimer’s disease, Parkinson’s disease, and epilepsy. Current clinical devices typically rely on millimeter-scale metallic electrodes, but their bulky design limits integration with fine neural structures, compromising high-resolution recordings and precise stimulation.  Miniaturization of electrodes offers the potential for higher spatial resolution, improving both neural signal decoding and stimulation focality. However, reducing electrode size decreases their effective surface area, increasing electrochemical impedance and limiting charge transfer capacity. This adversely affects the signal-to-noise ratio (SNR) in recordings and restricts safe charge injection during stimulation, posing risks to the surrounding tissue. Additionally, the mechanical mismatch between stiff electrodes and the soft, flexible neural tissue presents compatibility challenges. Hydrogels, with their mechanical softness, biocompatibility, and biofunctionality, offer a promising solution. In this project, we design micrometer-scale cellulose-based hydrogels to bridge the gap between neural electrodes and neural tissues, aiming to enhance interface compatibility and performance in peripheral nerve stimulation using noninvasive transcutaneous techniques with temporally interfering electric fields.

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